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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIK1 All Species: 7.88
Human Site: S366 Identified Species: 14.44
UniProt: P57059 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57059 NP_775490.2 783 84902 S366 A R Q P R P R S S D L S G L E
Chimpanzee Pan troglodytes XP_531484 783 84972 S366 A R Q P R P R S S D L S G L E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544912 898 97147 R491 P A R Q Q R P R S S D L S G F
Cat Felis silvestris
Mouse Mus musculus Q60670 779 85009 R368 P T R Q P Q L R S S D L S S L
Rat Rattus norvegicus Q9R1U5 776 84890 R368 P A R Q P Q L R N S D L S S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511894 801 88312 R373 T T R R H R P R S S E L S S F
Chicken Gallus gallus Q9IA88 798 88848 S366 G R Q Q R P R S S E I S N A E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 E418 Q V Q L I N P E N Q I V E T D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_569972 1398 149888 D750 M S S S S S F D S K A N L G Q
Honey Bee Apis mellifera XP_397175 718 80391 R350 A C W P S V A R T K E D K F K
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 G576 S S A A P S S G S S S S R R S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 E147 V H R D L K P E N L L L D S R
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 V268 F K N I S N G V Y T L P K F L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 69.2 N.A. 81.3 81.6 N.A. 70.4 66.6 N.A. 32 N.A. 28.8 36.5 24.5 N.A.
Protein Similarity: 100 99.6 N.A. 73.6 N.A. 86.2 86.3 N.A. 77 76.6 N.A. 44 N.A. 38 50.9 39.4 N.A.
P-Site Identity: 100 100 N.A. 6.6 N.A. 6.6 0 N.A. 6.6 60 N.A. 6.6 N.A. 6.6 13.3 13.3 N.A.
P-Site Similarity: 100 100 N.A. 20 N.A. 13.3 13.3 N.A. 13.3 73.3 N.A. 26.6 N.A. 20 26.6 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.2 27.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41 42.7 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 16 8 8 0 0 8 0 0 0 8 0 0 8 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 8 0 16 24 8 8 0 8 % D
% Glu: 0 0 0 0 0 0 0 16 0 8 16 0 8 0 24 % E
% Phe: 8 0 0 0 0 0 8 0 0 0 0 0 0 16 16 % F
% Gly: 8 0 0 0 0 0 8 8 0 0 0 0 16 16 0 % G
% His: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 0 0 0 0 0 16 0 0 0 0 % I
% Lys: 0 8 0 0 0 8 0 0 0 16 0 0 16 0 8 % K
% Leu: 0 0 0 8 8 0 16 0 0 8 31 39 8 16 24 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 16 0 0 24 0 0 8 8 0 0 % N
% Pro: 24 0 0 24 24 24 31 0 0 0 0 8 0 0 0 % P
% Gln: 8 0 31 31 8 16 0 0 0 8 0 0 0 0 8 % Q
% Arg: 0 24 39 8 24 16 24 39 0 0 0 0 8 8 8 % R
% Ser: 8 16 8 8 24 16 8 24 62 39 8 31 31 31 8 % S
% Thr: 8 16 0 0 0 0 0 0 8 8 0 0 0 8 0 % T
% Val: 8 8 0 0 0 8 0 8 0 0 0 8 0 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _